Combination Versus Sequential Single‐Agent Therapy in Metastatic Breast Cancer
نویسندگان
چکیده
منابع مشابه
Carboplatin in combination therapy for metastatic breast cancer.
BACKGROUND Anthracycline-based regimens have a limited role in patients with metastatic breast cancer due to cumulative cardiotoxicity and their common use in adjuvant chemotherapy. New nonanthracycline regimens are, therefore, needed for metastatic disease. Single-agent carboplatin is active in patients with previously untreated metastatic breast cancer, producing response rates of 20%-35%. Pr...
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Compared with treatment options for early-stage breast cancer, few data exist regarding the optimal use of chemotherapy for metastatic breast cancer (MBC). The choice of using a combination of cytotoxic chemotherapies vs sequential single agents is controversial. At the 6th European Breast Cancer Conference, the European School of Oncology Metastatic Breast Cancer Task Force convened an open de...
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In their review of combination vs sequential single-agent chemotherapy in advanced breast cancer, Cardoso et al. ( 1 ) highlight nine recent randomized trials and suggest that previous meta-analyses were heavily biased by the inclusion of clinical trials testing outdated chemotherapy regimens with serious methodological flaws, which often failed to mandate crossover. Although in general we are ...
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The chemotherapy of metastatic colorectal cancer (CRC) has undergone a succession of refinements. Through the biochemical modulation of 5-fluorouracil (5-FU) with folinic acid (FA), the use of infusional rather than bolus regimens and the combination of 5-FU/FA with other active agents (notably irinotecan), first-line response rates (RRs) of 40% can be achieved, with patients surviving up to 17...
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ژورنال
عنوان ژورنال: The Oncologist
سال: 2002
ISSN: 1083-7159,1549-490X
DOI: 10.1634/theoncologist.2002-0013